July 1, 1998Canadian Journal of Physiology and Pharmacology
The effect of sinus node depression on heart rate variability in humans using zatebradine, a selective bradycardic agent
Key result
Zatebradine significantly reduced heart rate variability at 60 minutes across all frequency bands, including a 26±5% reduction in high frequency power (p<0.001), compared to saline.
Why the study?
Does zatebradine reduce heart rate variability in patients without structural heart disease?
Population
36 patients without structural heart disease
Comparison
Zatebradine 10 mg intravenous infusion vs Isotonic saline intravenous infusion
Design
RCT, randomly assigned
Follow-up
60 min
Authors
Discussion
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Implication
Zatebradine reduces HRV; extends evidence that If current directly shapes spectral indices beyond rate slowing alone.
Study Design
Type
RCT (n=36)
Structured PICO
Does zatebradine reduce heart rate variability in patients without structural heart disease?
P
Population
36 patients without structural heart disease evaluated for heart rate variability changes over 60 minutes following zatebradine or saline infusion.
I
Intervention
Zatebradine 10 mg intravenous infusion
C
Comparator
Isotonic saline intravenous infusion
O
Outcome
Heart rate variability (HRV) recorded as power in the very low frequency (VLF, 0.003-0.040 Hz), low frequency (LF, 0.040-0.150 Hz), and high frequency (HF, 0.150-0.400 Hz) spectral bands as well as total power (TP, 0.003-0.400 Hz) during 5-min ECG acquisitions at 30 and 60 min following the start of the infusionsurrogate
Main Result
p-value: p=<0.001
Zatebradine significantly reduces heart rate variability by depressing sinus node response, indicating that normal sinus node function is a prerequisite for valid HRV research.
Cite This Study
Khaykin et al. (1998) conducted an RCT in No structural heart disease (n=36). Zatebradine vs. Isotonic saline was evaluated on Heart rate variability (HRV) in VLF, LF, and HF spectral bands at 60 min (p=<0.001). Zatebradine significantly reduced heart rate variability at 60 minutes across all frequency bands, including a 26±5% reduction in high frequency power (p<0.001), compared to saline.