Key result
Atrioventricular delay optimization using Doppler-derived dP/dt significantly improved LVEF (32.1% vs 27.5%, P<0.05) and NYHA class (2.1 vs 3.0, P<0.01) at 6 months compared to an empiric AV delay.
Why the study?
Does AV delay optimization by Doppler-derived LV dP/dt improve functional class and LVEF in patients receiving cardiac resynchronization therapy?
Cohort (n=38)
Does AV delay optimization by Doppler-derived LV dP/dt improve functional class and LVEF in patients receiving cardiac resynchronization therapy?
Absolute Event Rate: 32.1% vs 27.5%
p-value: p=<0.05
Optimizing AV delay using Doppler-derived LV dP/dt in CRT patients significantly improves functional class and LVEF at 6 months compared to an empiric AV delay.
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May support Doppler dP/dt AV optimization in CRT; leaves open randomized confirmation of benefit.
Morales et al. (2006) conducted a cohort in Cardiac resynchronization therapy (CRT) (n=38). Atrioventricular delay optimization by Doppler-derived left ventricular dP/dt vs. Empiric AV delay of 120 ms was evaluated on LV ejection fraction (LVEF) (p=<0.05). Atrioventricular delay optimization using Doppler-derived dP/dt significantly improved LVEF (32.1% vs 27.5%, P<0.05) and NYHA class (2.1 vs 3.0, P<0.01) at 6 months compared to an empiric AV delay.
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