Factors determining the relationship between adherence to treatment and quality of life in the elderly with chronic heart failure associated with arterial hypertension and chronic kidney disease: correlation analysis

The purpose of the work. To identify the factors that determine the relationship between adherence to treatment and QoL in the elderly with CHF on the background of AH and CKD, and to assess the possibilities of using the obtained data in clinical practice.Material and methods. The study included 93 patients from 60 to 74 years old with CHF on the background of AH and CKD. Clinical and laboratory studies, a questionnaire regarding the presence of side effects, an assessment of the quality of life using the Minnesota questionnaire and adherence to treatment according to the Morisky-Green scale were used in all the patients.Results. Correlation analysis revealed the following relationships: for adherence to QoL - -0.57 (-0.69; -0.42); for systolic blood pressure with QoL - 0.46 (0.28; 0.61) and with adherence - -0.35 (-0.52; -0.16;); for the creatinine with QоL - 0.35 (0.16; 0.52) and with adherence - -0.3 (- 0.47; -0.1); for EPI GFR with QoL - -0.46 (-0.61; -0.28) and with adherence - 0.33 (0.14; 0.5); for the 6-minute walk test with QoL - -0.65 (-0.78; -0.52) and with adherence - 0.49 (0.32; 0.63). For all identified relationships p is <0.05.Conclusions. In the elderly with CHF on the background of AH and CKD, correlations of moderate strength were found between the clinical and laboratory parameters of these diseases, QoL, and adherence to treatment. Identified pathogenetic links can be used to explain to the patient the need to follow the doctor's recommendations. A change in QoL can serve as a marker showing that some revising is needed in a patients’ treatment.