Key result
Overweight and obesity were associated with significantly elevated leptin levels in both children (27.65 vs 7.88 ng/ml) and adults with hypertension (31.72 vs 10.54 ng/ml) compared to healthy controls.
Why the study?
To evaluate anthropometric and hemodynamic parameters, as well as blood lipid and leptin alterations, in children and adults with overweight and obesity.
Are overweight and obesity associated with changes in lipid spectrum and leptin levels in children and adults?
Observational (n=233)
No
Are overweight and obesity associated with changes in lipid spectrum and leptin levels in children and adults?
Absolute Event Rate: 31.72% vs 10.54%
p-value: p=<0.01
Overweight and obesity in children and adults are associated with significant hyperleptinemia and proatherogenic dyslipidemia, highlighting the need for early intervention to prevent cardiovascular disease.
Obesity-associated hyperleptinemia in hypertensive children and adults warrants longitudinal studies; leaves open causal links to cardiovascular risk.
The aim: To evaluate anthropometric, hemodynamic parameters, as well as changes in blood and leptin lipid spectrum in children and adults with overweight and obesity. Materials and methods: We examined 68 overweight children and 90 patients with obesity in combination with stage 2, grade 2 AH who were electively inpatient. The control group consisted of practically healthy individuals – 20 adults and 55 children. Results: Obesity in childhood isaccompanied by the development of dyslipidemia, hypercholesterolemia, hyperleptinemia and hypertension, and in adulthood may be an additional risk factor for cardiovascular disease, in particular AH. According to the study, total leptin level in overweight children was significantly higher compared to the control group (p<0.01). The concentration of leptin in patients with hypertension in combination with obesity was 3 times higher compared to the control group (p<0.01) Conclusions: Thus, obesity or overweight, accompanied by hyperleptinemia and an increase in the proatherogenic fractions of the blood lipid spectrum, is an important problem that needs to be addressed in childhood to prevent cardiovascular disease in adulthood.
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Bochar et al. (2021) conducted an observational in Overweight, obesity, and arterial hypertension (n=233). Overweight and obesity vs. Healthy normal-weight individuals was evaluated on Leptin concentration (ng/ml) in adults (p=<0.01). Overweight and obesity were associated with significantly elevated leptin levels in both children (27.65 vs 7.88 ng/ml) and adults with hypertension (31.72 vs 10.54 ng/ml) compared to healthy controls.
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