What question did this study set out to answer?

This research aims to understand how ergonovine affects coronary arteries in dogs with induced atherosclerosis.

February 1, 1984Circulation

Selective hypercontraction caused by ergonovine in the canine coronary artery under conditions of induced atherosclerosis.

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Why the study?

Does endothelial denudation combined with a high-cholesterol diet increase the hypercontractile response of coronary arteries to ergonovine in a canine model?

Population

15 mongrel dogs with selective endothelial denudation of either the left circumflex coronary artery or left…

Comparison

Ergonovine administration vs Contralateral intact coronary arteries

Design

Preclinical

Follow-up

3 to 6 months

Authors

YKY KawachiKansai Electric Power (Japan)HTH TomoikeSakakibara Hospital YMYuji MaruokaChiba Institute of Technology

Discussion

Member takes

Implication

Hypothesis-generating for endothelial injury in coronary spasm; human studies required before clinical relevance.

Key Points

This research aims to understand how ergonovine affects coronary arteries in dogs with induced atherosclerosis.
Induced endothelial denudation in mongrel dogs
Administered a high-cholesterol diet for 3 to 6 months
Measured isometric tension in coronary artery strips exposed to ergonovine, serotonin, and phenylephrine.
Significant increase in coronary constriction after ergonovine in denuded arteries (p<0.05)
Lowered threshold concentrations for ergonovine response in denuded arteries
Microscopic changes showed intimal thickening but low lipid deposition after the high-cholesterol diet.

Structured PICO

Does endothelial denudation combined with a high-cholesterol diet increase the hypercontractile response of coronary arteries to ergonovine in a canine model?

Population

15 mongrel dogs with selective endothelial denudation of either the left circumflex coronary artery (LCX) or left anterior descending coronary artery (LAD) and fed a high-cholesterol diet (20 g/day) for 3 to 6 months.

Intervention

Ergonovine administration (intravenous in vivo, cumulative addition in vitro)

Comparator

Contralateral intact coronary arteries

Outcome

Coronary vasoconstriction and hypercontractile response measured arteriographically (in situ) and mechanographically (in vitro)surrogate

Endothelial denudation and a high-cholesterol diet induce localized hypersensitivity to ergonovine in canine coronary arteries, suggesting a link between atherosclerotic changes and coronary spasm.

Cite This Study

Kawachi et al. (1984) studied this question.

synapsesocial.com/papers/6a2066b8d1cd0ea0c19cd802 https://doi.org/10.1161/01.cir.69.2.441

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Selective hypercontraction caused by ergonovine in the canine coronary artery under conditions of induced atherosclerosis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Selective hypercontraction caused by ergonovine in the canine coronary artery under conditions of induced atherosclerosis.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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