This study identifies a novel multisite modulation pattern of anaerobic glycolysis in human hibernating myocardium, challenging traditional metabolic control concepts.
Answers are grounded in this paper and cite their sources.
Challenges traditional glycolytic control concepts in hibernating myocardium; leaves open whether multisite modulation informs viability assessment or therapy.
Myocardial hibernation represents an adaptation to sustained ischemia to maintain tissue vitality during severe supply-demand imbalance which is characterized by an increased glucose uptake. To elucidate this adaptive protective mechanism, the regulation of anaerobic glycolysis was investigated using human biopsies. In hibernating myocardium showing an increase in anaerobic glycolytic flux metabolizing exogenous glucose, the adjustment of flux through this pathway was analyzed by flux:metabolite co-responses. By this means, a previously unknown pattern of regulation using multisite modulation was found which largely differs from traditional concepts of metabolic control of the Embden-Meyerhof pathway in normal and diseased myocardium.
No takes yet. Share an insight, caveat, or question.
Vogt et al. (2002) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: