Population
Cultured vascular smooth muscle (VSM) cells from canine femoral artery
Design
Preclinical
Authors
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May support insulin-mediated vasodilation in animal vessels; leaves open translation to human hypertension or metabolic disease.
Insulin inhibits vascular smooth muscle contraction by stimulating Na(+)-K+ pump activity, leading to hyperpolarization and decreased Ca2+ influx.
Kahn et al. (1995) studied this question.
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