Key result
Higher dietary salt intake, measured by 24-h urinary sodium, was positively correlated with mean 24-h systolic (r=0.371, p=0.001) and diastolic (r=0.381, p=0.001) blood pressure variability.
Why the study?
Does dietary salt intake correlate with ambulatory blood pressure variability in non-diabetic hypertensive patients?
Cross-Sectional (n=136)
Does dietary salt intake correlate with ambulatory blood pressure variability in non-diabetic hypertensive patients?
Effect estimate: r = 0.371
p-value: p=0.001
Higher dietary salt intake, as measured by 24-hour urinary sodium, is independently associated with increased ambulatory blood pressure variability in non-diabetic hypertensive patients.
Should not yet change salt recommendations; leaves open whether reduction lowers ambulatory BP variability in hypertension.
High dietary salt intake was reported to increase blood pressure by numerous studies, but no study has investigated the effect of dietary salt intake on blood pressure variability (BPV). This study aimed to determine if daily salt intake is related to ambulatory BPV. The study included 136 primary hypertensive patients (92 male, 44 female) with a mean age of 50.7 ± 11.1 years. All the patients underwent 24-h ambulatory blood pressure monitoring to determine both the 24-h systolic and 24-h diastolic BPV. 24-h urine sodium was measured. The correlation between BPV and 24-h urinary sodium was investigated. Logarithmic transformation of 24-h urinary sodium [log(24-h urinary sodium)] was positively correlated with the mean 24-h systolic ARV, and nighttime systolic ARV (r = 0.371 and p = 0.001, r = 0.329 and p = 0.028, respectively). Similarly, log(24-h urinary sodium) was positively correlated with mean 24-h diastolic ARV and nighttime diastolic ARV (r = 0.381 and p = 0.001, r = 0.320 and p = 0.020 respectively). Log(24-h urinary sodium) was an independent predictor of BPV based on multivariate regression analysis. Dietary salt intake might play a role in the pathogenesis of ambulatory BPV. En numerosos estudios se ha señalado que el consumo elevado de sal aumenta la presión arterial; no obstante, no se ha investigado el efecto de la ingesta alimenticia de sal sobre la variabilidad de la presión arterial (VPA). El objetivo de este estudio fue determinar si el consumo diario de sal está relacionado con la VPA ambulatoria. En el estudio se incluyeron 136 pacientes hipertensos esenciales (92 hombres y 44 mujeres) con una edad media de 50,7 ± 11,1 años. Todos los pacientes se sometieron a una monitorización ambulatoria de la presión arterial de 24 h para determinar la VPA sistólica y diastólica de 24 h. Se midió la natriuria de 24 h y se estudió la correlación de la misma con la VPA. La transformación logarítmica de la natriuria de 24 h (log [natriuria 24 h]) se relacionó con certeza con el índice Average Real Variability (ARV) sistólico de 24 h y el ARV sistólico nocturno medios (r = 0,371 y p = 0,001, r = 0,329 y p = 0,028, respectivamente). De forma parecida, el log [natriuria 24 h] se relacionó con seguridad con el ARV diastólico de 24 h y el ARV diastólico nocturno medios (r = 0,381 y p = 0,001, r = 0,320 y p = 0,020, respectivamente). El log [natriuria 24 h] fue una variable independiente de la VPA, según el análisis de regresión multivariante. Es posible que el consumo de sal intervenga en la patogénesis de la VPA ambulatoria.
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Özkayar et al. (2016) conducted a cross-sectional in Primary hypertension (non-diabetic) (n=136). Dietary salt intake (24-h urinary sodium) was evaluated on Mean 24-h systolic Average Real Variability (ARV) (r = 0.371, p=0.001). Higher dietary salt intake, measured by 24-h urinary sodium, was positively correlated with mean 24-h systolic (r=0.371, p=0.001) and diastolic (r=0.381, p=0.001) blood pressure variability.
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