Key result
Higher dietary sodium is linked to greater nocturnal SBP variability in hypertensive patients.
Why the study?
The association between dietary sodium intake and blood pressure variability in hypertensive patients remains unclear.
Is dietary sodium intake associated with elevated blood pressure variability in Chinese patients with hypertension?
Observational (n=235)
No
Is dietary sodium intake associated with elevated blood pressure variability in Chinese patients with hypertension?
Effect estimate: β = 0.224
p-value: p=<0.001
Higher dietary sodium intake is independently associated with increased nocturnal blood pressure variability in Chinese patients with essential hypertension.
Higher sodium excretion was associated with nocturnal BP variability; hypothesis-generating for sodium reduction in hypertension, needs prospective confirmation.
BACKGROUND: The association between dietary sodium intake and blood pressure variability (BPV) in hypertensive patients remains unclear. The objective of this study was to demonstrate whether dietary sodium intake is a predictor of elevated BPV in Chinese patients with hypertension. METHODS: A total of 235 patients with essential hypertension were enrolled in the Department of Cardiology, Chinese People's Liberation Army (PLA) General Hospital in 2018 to 2019, all of whom underwent 24-h ambulatory blood pressure monitoring. BPV was calculated as the standard deviation (SD), coefficient of variation (CV), variation independent of mean (VIM) of blood pressure measurements, respectively, and divided into diurnal systolic BPV (SBPV), diurnal diastolic BPV (DBPV), nocturnal SBPV, and nocturnal DBPV. 24-h urine samples were collected to measure 24-h urine sodium excretion, which represents dietary sodium intake. The relationship between dietary sodium intake and BPV was analyzed by using Spearman correlations and multiple linear regression analysis. RESULTS: Nocturnal SBPV-SD, CV, VIM, and nocturnal DBPV-SD in the high urine sodium excretion group were significantly higher than those in the medium and low urine sodium excretion groups, whereas diurnal SBPV-SD, CV, VIM, diurnal DBPV-SD, CV, VIM, and nocturnal DBPV-CV, VIM were not. Using the Spearman correlation analysis, we found a linear correlation between 24-h urine sodium excretion and nocturnal SBPV-SD, CV, VIM (SD, r = 0.22, P = 0.001; CV, r = 0.17, P = 0.009; VIM, r = 0.16, P = 0.020), nocturnal DBPV-SD (r = 0.21, P = 0.001), respectively. After further adjusting for confounding factors by multiple linear regression, the positive correlations remained between 24-h urine sodium excretion and nocturnal SBPV-SD, CV, VIM (SD, β = 0.224, P < 0.001; CV, β = 0.211, P = 0.001; VIM, β = 0.213, P = 0.001), nocturnal DBPV (SD, β = 0.215, P = 0.001), respectively. CONCLUSIONS: Dietary sodium intake is associated with nocturnal SBPV in Chinese patients with hypertension.
No takes yet. Share an insight, caveat, or question.
Wang et al. (2020) conducted an observational in essential hypertension (n=235). Dietary sodium intake (24-h urine sodium excretion) vs. Medium and low urine sodium excretion groups was evaluated on Nocturnal systolic blood pressure variability (SBPV-SD) (β = 0.224, p=<0.001). Higher dietary sodium intake was significantly associated with increased nocturnal systolic blood pressure variability in Chinese patients with hypertension (β = 0.224, P<0.001).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: