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June 1, 1986The Journal of General PhysiologyOpen Access

"Creep currents" in single frog atrial cells may be generated by electrogenic Na/Ca exchange.

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Population

Single frog atrial cells

Design

Preclinical

Authors

JHJoseph R. HumeElectrophysiologyAUA. UeharaUniversity of Tsukuba

Discussion

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Implication

Supports electrogenic Na/Ca exchange in frog atrial cells; leaves open its role in mammalian cardiac electrophysiology.

Structured PICO

P
Population
Single frog atrial cells
I
Intervention
Na loading and voltage-clamp pulses (depolarizing and hyperpolarizing)
O
Outcome
Characteristics of creep currents (current-voltage relations, reversal potential) and correlation with mechanical activitysurrogate

Creep currents in single frog atrial cells are likely generated by an electrogenic Na/Ca exchange mechanism.

Cite This Study

Hume et al. (1986) studied this question.

synapsesocial.com/papers/6a20798acbc595e19031812ehttps://doi.org/10.1085/jgp.87.6.857
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Contractions induced by a calcium‐triggered release of calcium from the sarcoplasmic reticulum of single skinned cardiac cells.1975 · 683 citations
  2. 2Control of cardiac contractility at the cellular level1983 · 151 citations
  3. 3Sarcomere length-resting tension relation in single frog atrial cardiac cells.1979 · 57 citations
  4. 4Sodium-calcium exchange in regulation of cardiac contractility. Evidence for an electrogenic, voltage-dependent mechanism.1979 · 186 citations
  5. 5Membrane current and contraction in frog atrial fibres1972 · 76 citations