What question did this study set out to answer?

This study aims to evaluate the safety and effectiveness of different dosages and combinations of antihypertensive agents.

July 11, 1994Archives of Internal Medicine

A Multifactorial Trial Design to Assess Combination Therapy in Hypertension

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Why the study?

Does combination therapy with bisoprolol and hydrochlorothiazide reduce blood pressure in patients with mild to moderate essential hypertension?

Population

512 patients with mild to moderate essential hypertension

Comparison

Bisoprolol and hydrochlorothiazide in all… vs Placebo or alternative dose combinations

Design

RCT, randomized, 3 x 4 factorial trial, double-blind, placebo-controlled

Follow-up

12 weeks

Authors

WFWilliam H. FrishmanWestchester Medical Center

Discussion

Member takes

Implication

Supports low-dose bisoprolol-hydrochlorothiazide as initial therapy in mild hypertension; extends RCT evidence for fixed-dose combinations.

Key Points

This study aims to evaluate the safety and effectiveness of different dosages and combinations of antihypertensive agents.
Conducted a randomized, double-blind, placebo-controlled, 3 x 4 factorial trial with 512 patients
Patients received bisoprolol (0, 2.5, 10, or 40 mg) and hydrochlorothiazide (0, 6.25, or 25 mg) in various combinations
Monitored diastolic and systolic blood pressures over a 12-week period
Combination of bisoprolol and hydrochlorothiazide showed additive effects on blood pressure reduction
A dosage of 6.25 mg/d of hydrochlorothiazide significantly reduced blood pressure without causing hypokalemia
61% of patients reached a diastolic blood pressure below 90 mm Hg with the low-dose combination therapy

Structured PICO

Does combination therapy with bisoprolol and hydrochlorothiazide reduce blood pressure in patients with mild to moderate essential hypertension?

Population

512 patients with mild to moderate essential hypertension

Intervention

Bisoprolol (0, 2.5, 10, or 40 mg) and hydrochlorothiazide (0, 6.25, or 25 mg) in all possible combinations, once-daily

Comparator

Placebo (0 mg bisoprolol and 0 mg hydrochlorothiazide) or alternative dose combinations

Outcome

Diastolic and systolic blood pressuressurrogate

A low-dose combination of bisoprolol and hydrochlorothiazide provides effective blood pressure reduction with a favorable safety profile, offering a rational alternative for initial hypertension treatment.

Cite This Study

William H. Frishman (1994) studied this question.

synapsesocial.com/papers/6a2079afcbc595e19031813a https://doi.org/10.1001/archinte.1994.00420130048008

Topics

Hypertension management

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Implication

Supports low-dose bisoprolol-hydrochlorothiazide as initial therapy in mild hypertension; extends RCT evidence for fixed-dose combinations.

A Multifactorial Trial Design to Assess Combination Therapy in Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

A Multifactorial Trial Design to Assess Combination Therapy in Hypertension

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider