Why the study?
Does combination therapy with diltiazem SR and hydrochlorothiazide improve blood pressure reduction compared to monotherapy or placebo in patients with mild to moderate hypertension?
Population
297 patients with mild to moderate hypertension
Comparison
Diltiazem SR and hydrochlorothiazide combination… vs Placebo, diltiazem SR monotherapy, or…
Design
RCT, Randomized to receive placebo, 1 of 4 doses of diltiazem SR monotherapy…
Follow-up
6 weeks
Authors
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Supports initial combination over monotherapy for greater BP control in mild-moderate hypertension; confirms additive efficacy of diltiazem SR plus hydrochlorothiazide.
Does combination therapy with diltiazem SR and hydrochlorothiazide improve blood pressure reduction compared to monotherapy or placebo in patients with mild to moderate hypertension?
Combination therapy with diltiazem SR and hydrochlorothiazide provides additive blood pressure reduction compared to either drug alone in mild to moderate hypertension.
J. F. Burris (1990) studied this question.
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