Why the study?
Does diltiazem compared to hydrochlorothiazide improve blood pressure and endocrine responses in patients with essential hypertension?
Population
40 patients (aged 28-66 years) with essential hypertension
Comparison
Diltiazem for 14 weeks vs Hydrochlorothiazide (HCTZ) for 14 weeks
Design
RCT, randomized, double-blind
Follow-up
14 weeks
Authors
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Diltiazem matches HCTZ for BP reduction in essential hypertension; confirms comparable renin-angiotensin and PGE2-M activation.
Does diltiazem compared to hydrochlorothiazide improve blood pressure and endocrine responses in patients with essential hypertension?
Diltiazem and hydrochlorothiazide provide comparable blood pressure reduction in essential hypertension, and both activate the renin-angiotensin system accompanied by increased production of PGE2-M.
Stephen L. Swartz (1987) studied this question.
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