Why the study?
Does diltiazem improve systemic and regional hemodynamics in patients with hypertension?
Population
10 patients (9 with mild-to-moderate essential hypertension and 1 with primary aldosteronism)
Design
Cohort
Follow-up
4 weeks
Authors
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Short-term diltiazem was associated with sustained BP reduction in hypertension; leaves open long-term efficacy and safety in randomized trials.
Does diltiazem improve systemic and regional hemodynamics in patients with hypertension?
Intravenous followed by short-term oral diltiazem effectively lowers mean arterial pressure and improves renal hemodynamics without altering humoral responses in hypertensive patients.
Amodeo et al. (1986) studied this question.
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