Effects of hydrochlorothiazide and diltiazem on reflex vasoconstriction in hypertension.
Key result
Diltiazem, unlike hydrochlorothiazide, abolishes forearm vascular resistance responses to lower body negative pressure in hypertension.
- n=18
Why the study?
Does hydrochlorothiazide or diltiazem alter reflex vasoconstriction in subjects with mild to moderate hypertension?
Population
18 subjects with mild to moderate hypertension (supine diastolic pressure, 95-114 mm Hg)
Comparison
Hydrochlorothiazide or diltiazem for 12 weeks vs Pre-treatment baseline
Design
Cohort
Follow-up
12 weeks
Authors
Discussion
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Member takes
Implication
May blunt reflex vasoconstriction with diltiazem but not hydrochlorothiazide; hypothesis-generating and should not yet change practice.
Structured PICO
Does hydrochlorothiazide or diltiazem alter reflex vasoconstriction in subjects with mild to moderate hypertension?
P
Population
18 subjects with mild to moderate hypertension (supine diastolic pressure 95-114 mm Hg) treated for 12 weeks.
I
Intervention
Hydrochlorothiazide (25-50 mg b.i.d., n=10) or diltiazem (120-180 mg b.i.d., n=8) for 12 weeks
C
Comparator
Pre-treatment baseline (after 2-4 weeks of placebo)
O
Outcome
Reflex humoral, hemodynamic, and vascular responses to graded lower body negative pressure and head-up tilt (mean arterial pressure, forearm vascular resistance, plasma norepinephrine, and renin)surrogate
Diltiazem, but not hydrochlorothiazide, abolishes forearm vascular resistance responses to lower body negative pressure in patients with mild to moderate hypertension.
Cite This Study
Mohanty et al. (1987) studied mild to moderate hypertension (n=18). Diltiazem vs. Hydrochlorothiazide was evaluated on Forearm vascular resistance responses to lower body negative pressure. Diltiazem, but not hydrochlorothiazide, virtually abolished forearm vascular resistance responses to lower body negative pressure in subjects with mild to moderate hypertension.