What question did this study set out to answer?

To evaluate the safety and additive blood-pressure-lowering efficacy of a slow-release formulation of diltiazem hydrochloride alone and combined with hydrochlorothiazide in mild to moderate hypertension.

March 16, 1990JAMA

An Assessment of Diltiazem and Hydrochlorothiazide in Hypertension

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Authors

JBJames F. BurrisNational Oceanography Centre

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Implication

Randomized trial demonstrates additive blood pressure reductions with diltiazem and hydrochlorothiazide in hypertension, indicating enhanced efficacy of combination therapy.

Key Points

To evaluate the safety and additive blood-pressure-lowering efficacy of a slow-release formulation of diltiazem hydrochloride alone and combined with hydrochlorothiazide in mild to moderate hypertension.
Multicenter, factorial-design randomized trial of 297 patients with mild to moderate hypertension evaluated after a 4- to 6-week placebo run-in phase.
Patients were randomly assigned to 6 weeks of treatment with placebo, 1 of 4 doses of diltiazem SR monotherapy, 1 of 3 doses of hydrochlorothiazide monotherapy, or 1 of 12 combination regimens.
Combination therapy reduced blood pressure by an overall mean of 8.0 mm Hg systolic and 3.0 mm Hg diastolic compared with diltiazem SR alone, and 4.0 mm Hg systolic and 3.5 mm Hg diastolic compared with hydrochlorothiazide alone.
At maximum doses, goal blood pressure was achieved in 75% of patients receiving combination therapy, compared to 57% receiving diltiazem SR monotherapy and 50% receiving hydrochlorothiazide monotherapy.

Cite This Study

James F. Burris (1990) studied this question.

synapsesocial.com/papers/6a83078cc4b5dbf8331f26a3 https://doi.org/10.1001/jama.1990.03440110073031

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Implication

Randomized trial demonstrates additive blood pressure reductions with diltiazem and hydrochlorothiazide in hypertension, indicating enhanced efficacy of combination therapy.

An Assessment of Diltiazem and Hydrochlorothiazide in Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

An Assessment of Diltiazem and Hydrochlorothiazide in Hypertension

Discussion

Member takes

Implication

Key Points

Cite This Study

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