Key result
Coadministration of diltiazem and hydrochlorothiazide did not significantly alter the steady-state pharmacokinetics of either drug, including diltiazem AUCss (771 vs 688 ng x h mL-1; p > 0.05).
Why the study?
Does the combination of diltiazem and hydrochlorothiazide alter their steady-state pharmacokinetics in healthy male volunteers?
Population
20 healthy male volunteers
Comparison
Combination of diltiazem and hydrochlorothiazide vs Diltiazem alone and hydrochlorothiazide alone
Design
RCT, randomized, crossover, open
Authors
Loading...
Supports safe coadministration without pharmacokinetic dose adjustments; confirms absence of interaction in healthy volunteers.
RCT (n=20)
Open-label
Crossover
Does the combination of diltiazem and hydrochlorothiazide alter their steady-state pharmacokinetics in healthy male volunteers?
Absolute Event Rate: 771% vs 688%
p-value: p=> 0.05
Coadministration of diltiazem and hydrochlorothiazide does not result in a clinically significant pharmacokinetic drug-drug interaction.
Weir et al. (1998) conducted an RCT in Healthy volunteers (n=20). Diltiazem and hydrochlorothiazide combination vs. Diltiazem alone and hydrochlorothiazide alone was evaluated on Diltiazem area under the plasma concentration-time curve (AUCss) (p=> 0.05). Coadministration of diltiazem and hydrochlorothiazide did not significantly alter the steady-state pharmacokinetics of either drug, including diltiazem AUCss (771 vs 688 ng x h mL-1; p > 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: