Why the study?
Does co-administration of diltiazem and quinidine alter their respective pharmacokinetics and pharmacodynamics in healthy volunteers?
Population
12 fasting, healthy male volunteers (mean age 24 +/- 5 years, weight 75 +/- 10 kg)
Comparison
Single oral dose of diltiazem or quinidine on a… vs Single oral dose of diltiazem or quinidine alone
Design
Other
Authors
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Co-administration may increase quinidine exposure warranting caution; leaves open need for dose adjustment in patients.
Does co-administration of diltiazem and quinidine alter their respective pharmacokinetics and pharmacodynamics in healthy volunteers?
Diltiazem significantly decreases the clearance of quinidine, increasing its exposure, which may require dose adjustments when these drugs are co-administered.
Laganière et al. (1996) studied this question.
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