Key result
Co-administration of 10 mg diazepam with 250 mg quinidine sulphate had no significant effect on quinidine disposition kinetics, including AUC and Cmax (p > 0.05).
Why the study?
Does diazepam alter the pharmacokinetics of quinidine in healthy volunteers?
Does diazepam alter the pharmacokinetics of quinidine in healthy volunteers?
Diazepam does not significantly alter the pharmacokinetics of quinidine in healthy volunteers.
Answers are grounded in this paper and cite their sources.
No PK interaction seen in healthy volunteers; leaves open relevance for patients on chronic therapy or with comorbidities.
Influence of diazepam on the pharmacokinetics of quinidine was studied in eight healthy human volunteers by administering 250 mg of quinidine sulphate either alone or in combination with 10 mg diazepam in a cross-over study. Quinidine in the biological samples was estimated fluorimetrically. Comparison of various pharmacokinetic parameters of quinidine (Cmax 2.165 +/- 0.457 vs 2.239 +/- 0.338 micrograms/ml, Tmax 2 +/- 0.71 vs 2.13 +/- 0.58 h, T1/2 7.004 +/- 1.302 vs 7.82 +/- 1.63 h, Cls/f 153.63 +/- 45.65 vs 134.87 +/- 31 ml/h/kg, AUC0-alpha 22.131 +/- 6.118 vs 24.321 +/- 4.924 micrograms.h/ml) by means of a two tailed t-test revealed no significant (p > 0.05) effect of diazepam on quinidine disposition kinetics.
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Rao et al. (1995) studied Healthy volunteers (n=8). Diazepam added to quinidine sulphate vs. 250 mg quinidine sulphate alone was evaluated on AUC0-alpha of quinidine (p=> 0.05). Co-administration of 10 mg diazepam with 250 mg quinidine sulphate had no significant effect on quinidine disposition kinetics, including AUC and Cmax (p > 0.05).
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