Why the study?
Does combination therapy with sustained-release diltiazem and hydrochlorothiazide improve blood pressure reduction compared to monotherapy or placebo in patients with essential hypertension?
Population
298 adults of either sex with stable essential hypertension.
Comparison
Combination therapy with sustained-release… vs Monotherapy with sustained-release diltiazem 120…
Design
RCT, randomized, parallel-group, double-blind, placebo-controlled
Follow-up
6 weeks
Authors
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Supports preferring diltiazem-HCTZ combination over monotherapy for essential hypertension; confirms additive BP-lowering effects in this RCT.
Does combination therapy with sustained-release diltiazem and hydrochlorothiazide improve blood pressure reduction compared to monotherapy or placebo in patients with essential hypertension?
Combination therapy with sustained-release diltiazem and hydrochlorothiazide provides superior blood pressure reduction compared to either agent alone in patients with essential hypertension.
Pool et al. (1993) studied this question.
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