Why the study?
Does sustained-release diltiazem 300 mg reduce blood pressure more effectively than enalapril 20 mg in patients with mild to moderate arterial hypertension?
Population
96 patients with mild to moderate arterial hypertension
Comparison
Sustained-release diltiazem 300 mg once daily OR… vs Enalapril 20 mg once daily for 28 days
Design
RCT, randomized to three parallel groups, double-blind
Follow-up
28 days
Authors
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Supports preferring sustained-release diltiazem over enalapril in mild-moderate hypertension; extends head-to-head RCT evidence for CCBs versus ACEIs.
Does sustained-release diltiazem 300 mg reduce blood pressure more effectively than enalapril 20 mg in patients with mild to moderate arterial hypertension?
Sustained-release diltiazem 300 mg monotherapy provided a significantly greater reduction in diastolic blood pressure compared to enalapril 20 mg monotherapy in patients with mild to moderate hypertension over 28 days.
Fermé et al. (1990) studied this question.
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