Why the study?
Does sustained-release diltiazem reduce blood pressure comparably to enalapril in patients with mild to moderate hypertension?
Population
147 patients with mild to moderate hypertension
Comparison
Sustained-release diltiazem 120 or 180 mg twice… vs Enalapril 10 or 20 mg once daily
Design
Cohort
Follow-up
14 weeks
Authors
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May support comparable BP control with diltiazem versus enalapril; leaves open confirmation in randomized hypertension trials.
Does sustained-release diltiazem reduce blood pressure comparably to enalapril in patients with mild to moderate hypertension?
Sustained-release diltiazem is as effective and well-tolerated as enalapril for the treatment of mild to moderate hypertension, with combination therapy being a viable option for monotherapy non-responders.
Weir et al. (1994) studied this question.
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