December 5, 2008The Nephron journals/Nephron journals
Angiotensin-Converting Enzyme Inhibitor versus Calcium Antagonist in the Treatment of Hypertension
Key result
Enalapril and diltiazem decreased blood pressure from 154/102 mm Hg to 135/96 mm Hg and 140/98 mm Hg respectively, with individual response to one agent not predicting response to the other.
Why the study?
Does enalapril compared to diltiazem improve blood pressure in patients with essential hypertension?
Population
16 patients with essential hypertension
Comparison
Enalapril 20 mg once daily for 6 weeks vs Diltiazem 120 mg twice daily for 6 weeks
Design
RCT, The sequence of the treatment phases was randomly allocated
Follow-up
2 consecutive 6-week periods
Authors
Discussion
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Implication
Both agents lower BP effectively in essential hypertension; supports sequential trials of alternate classes when initial response is inadequate.
Study Design
Type
RCT (n=16)
Randomization
randomly allocated
Structured PICO
Does enalapril compared to diltiazem improve blood pressure in patients with essential hypertension?
P
Population
16 patients with essential hypertension treated in a randomized crossover design for two 6-week periods.
I
Intervention
Enalapril 20 mg once daily for 6 weeks
C
Comparator
Diltiazem 120 mg twice daily for 6 weeks
O
Outcome
Blood pressuresurrogate
Both enalapril and diltiazem effectively lower blood pressure in essential hypertension, but individual response to one agent does not predict response to the other.
Cite This Study
Brunner et al. (2008) conducted an RCT in essential hypertension (n=16). Enalapril vs. Diltiazem (120 mg twice daily) was evaluated on Blood pressure. Enalapril and diltiazem decreased blood pressure from 154/102 mm Hg to 135/96 mm Hg and 140/98 mm Hg respectively, with individual response to one agent not predicting response to the other.