Why the study?
Does once daily administration of slow-release diltiazem reduce blood pressure as effectively as twice daily administration in patients with mild to moderate essential hypertension?
Does once daily administration of slow-release diltiazem reduce blood pressure as effectively as twice daily administration in patients with mild to moderate essential hypertension?
Twice daily administration of slow-release diltiazem is more effective at lowering blood pressure than once daily administration of the same total dose in patients with essential hypertension.
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Favors twice-daily slow-release diltiazem for greater BP reduction; confirms dosing frequency affects efficacy at equal total daily dose.
Nikkilä et al. (1991) studied this question.
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