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January 1, 1998Hypertension

Dissociation Between Muscle and Skin Sympathetic Nerve Activity in Essential Hypertension, Obesity, and Congestive Heart Failure

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Why the study?

Is skin sympathetic nerve activity increased in patients with essential hypertension, obesity, and congestive heart failure compared to healthy controls?

Population

42 subjects including 10 untreated mild essential hypertensive, 12 untreated normotensive obese, 10 mild…

Comparison

Measurement of muscle and skin sympathetic nerve… vs Normotensive lean healthy control subjects

Design

Cross-sectional, Muscle and skin nerve measurements were made in a randomized…

Authors

GGGuıdo GrassıMCM. ColomboGSGino Seravalle

Discussion

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Overview

Muscle-specific sympathetic activation in hypertension, obesity, and HF should not yet alter practice; leaves open targeted sympatholysis for future trials.

Key Points

  • Investigate the relationship between muscle and skin sympathetic nerve activity in essential hypertension, obesity, and heart failure.
  • Measured sympathetic nerve activity in muscle and skin using microneurographic technique.
  • Included 10 hypertensive, 12 obese, 10 heart failure, and 10 healthy control subjects.
  • Data collection occurred in a quiet, controlled environment over two 30-minute periods.
  • Muscle sympathetic nerve activity was significantly higher in hypertensive (33.3±1.7), obese (42.2±2.8), and heart failure (55.8±4.3) subjects compared to controls (23.9±1.6) with P<0.01.
  • Skin sympathetic nerve activity was equivalent across all groups, demonstrating marked reactivity to acoustic stimuli.
  • Indicates a dissociation in sympathetic nerve activation between muscle and skin across different cardiovascular conditions.

Structured PICO

Is skin sympathetic nerve activity increased in patients with essential hypertension, obesity, and congestive heart failure compared to healthy controls?

P
Population
42 subjects including 10 untreated mild essential hypertensive, 12 untreated normotensive obese, 10 mild (New York Heart Association class II) heart failure, and 10 normotensive lean healthy control subjects
I
Intervention
Measurement of muscle and skin sympathetic nerve activity using microneurographic technique (peroneal nerve)
C
Comparator
Normotensive lean healthy control subjects
O
Outcome
Muscle and skin sympathetic nerve activity quantified as bursts/min and bursts per 100 heart beatssurrogate

Sympathetic activation in hypertension, obesity, and heart failure is not uniformly distributed across the cardiovascular system, as muscle but not skin sympathetic nerve activity is increased.

Cite This Study

Grassı et al. (1998) studied this question.

synapsesocial.com/papers/6a207a04fb035751fb317d95https://doi.org/10.1161/01.hyp.31.1.64
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