Key result
Talin contains at least three distinct actin-binding sites, each adjacent to a vinculin-binding site, with the N- and C-terminal regions exhibiting distinct localization and functional properties.
Population
Chicken talin, with sequence comparisons to mouse, Caenorhabditis elegans, Dictyostelium discoideum, and…
Design
Preclinical
Authors
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Advances talin domain mapping in cell adhesion; leaves open validation in cardiovascular mechanotransduction models.
Talin contains three distinct actin-binding sites, each adjacent to a vinculin-binding site, with the N- and C-terminal regions exhibiting different localization and effects on actin stress fibres.
Hemmings et al. (1996) studied this question. Talin fusion proteins was evaluated on Identification and characterization of actin-binding sites. Talin contains at least three distinct actin-binding sites, each adjacent to a vinculin-binding site, with the N- and C-terminal regions exhibiting distinct localization and functional properties.
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