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January 14, 2020Open Access

Quantitative analysis of left atrial myocardial function and compliance in patients with pre-eclampsia

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Why the study?

Pre-eclampsia is a severe obstetric complication linked to cardiovascular disorders, but left atrial function and its cardiovascular adaptation changes have not been adequately addressed.

Does pre-eclampsia impair left atrial myocardial function and compliance compared to normotensive pregnancy and nonpregnant controls?

Population

Nonpregnant controls (n=39), normotensive pregnant women (n=40), and pre-eclampsia patients (n=43)

Comparison

Pre-eclampsia patients vs normotensive pregnant women vs nonpregnant controls

Design

Speckle tracking echocardiography comparative study

Key result

Pre-eclampsia is associated with significantly impaired left atrial myocardial function, including reduced global longitudinal strain (31.87% vs 35.87% in normotensive pregnancy) and decreased atrial compliance.

Authors

FSFei SunYLYong LiWWWugang Wang

Discussion

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Member takes

Overview

Supports closer LA function surveillance in pre-eclampsia; leaves open prognostic implications and need for longitudinal studies.

Study Design

Type

Cross-Sectional (n=122)

Multicenter

No

Structured PICO

Does pre-eclampsia impair left atrial myocardial function and compliance compared to normotensive pregnancy and nonpregnant controls?

P
Population
122 women, including 43 with pre-eclampsia, 40 with normotensive pregnancies, and 39 healthy nonpregnant controls, evaluated for left atrial myocardial function using speckle tracking echocardiography.
O
Outcome
Left atrial myocardial deformation characteristics (LAGLS, LASr, LAScd, LASct) and LA compliance (LASr/(E/e')) measured by speckle tracking echocardiographysurrogate

Main Result

Absolute Event Rate: 31.87% vs 35.87%

p-value: p=<0.05

Limitations

  • Apical two-chamber view was used to assess LA strain instead of the apical four-chamber view.
  • Commercial-specific LA-dedicated software was used, so findings may not apply to vendor-independent software.
  • The study focuses on acute cardiac impairment during pregnancy rather than postpartum.
  • Relatively small sample size from a single center.
  • Measurement of LA strain in a single apical view
  • Use of commercial-specific LA-dedicated software, which may not apply to vendor-independent software
  • Focuses on acute cardiac impairment in PE during pregnancy rather than thereafter
  • Relatively small number of patients in a single center

Cite This Study

Sun et al. (2020) conducted a cross-sectional in Pre-eclampsia (n=122). Pre-eclampsia vs. Normotensive pregnancy and nonpregnant controls was evaluated on Left atrial global longitudinal strain (LAGLS) (p=<0.05). Pre-eclampsia is associated with significantly impaired left atrial myocardial function, including reduced global longitudinal strain (31.87% vs 35.87% in normotensive pregnancy) and decreased atrial compliance.

synapsesocial.com/papers/6a207bbc04d2adee4bf4950ehttps://doi.org/10.21203/rs.2.20779/v1
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