What question did this study set out to answer?

This research aims to evaluate the impact of captopril on renal function in patients with renal-artery stenosis.

February 17, 1983New England Journal of Medicine

Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney

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Why the study?

Does captopril induce functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney?

Population

Patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney

Design

Other

Authors

DHDonald E. HricikUniversity Hospitals of Cleveland PBPhilip J. BrowningUniversity of Maryland, Baltimore RKRichard I. KopelmanTufts University

Discussion

Member takes

Implication

Supports caution with captopril in bilateral renal-artery stenosis; leaves open need for confirmatory trials.

Key Points

This research aims to evaluate the impact of captopril on renal function in patients with renal-artery stenosis.
Inclusion of patients with bilateral renal-artery stenoses or solitary kidney renal-artery stenosis.
Assessment of renal function changes following captopril administration.
Patients exhibited significant functional renal insufficiency after starting captopril treatment.
Event rates of renal impairment were notably different depending on the severity of stenosis.

Structured PICO

Does captopril induce functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney?

Population

Patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney

Intervention

Captopril

Outcome

Functional renal insufficiencysafety

Captopril can induce functional renal insufficiency in patients with bilateral renal-artery stenoses or renal-artery stenosis in a solitary kidney.

Cite This Study

Hricik et al. (1983) studied this question.

synapsesocial.com/papers/6a207cfba25331481ccd3fce https://doi.org/10.1056/nejm198302173080706

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Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Captopril-Induced Functional Renal Insufficiency in Patients with Bilateral Renal-Artery Stenoses or Renal-Artery Stenosis in a Solitary Kidney

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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