Key result
Epicardial fat exhibited high expression of UCP-1 and beige adipocyte-specific markers compared to visceral and subcutaneous fat depots, where UCP-1 was undetectable.
Population
Middle-aged patients with severe coronary atherosclerosis or valvular heart disease
Comparison
Gene expression analysis and morphological… vs Visceral paracardial fat and subcutaneous fat
Design
Cross-sectional
Authors
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Epicardial fat's beige features may influence cardiac metabolism; hypothesis-generating cross-sectional data leave open any clinical role.
Observational
No
Human epicardial fat possesses molecular features characteristic of beige lineage adipocytes, including relatively abundant UCP-1.
Sacks et al. (2013) conducted an observational in Severe coronary atherosclerosis or valvular heart disease. Epicardial fat vs. Visceral paracardial and subcutaneous fat was evaluated on Gene expression profile and morphology (UCP-1 abundance). Epicardial fat exhibited high expression of UCP-1 and beige adipocyte-specific markers compared to visceral and subcutaneous fat depots, where UCP-1 was undetectable.