Key result
Heart failure was associated with significantly higher frequencies of osteopontin-expressing CD4+ T cells (27.3% vs 16.7%) and plasma osteopontin levels compared to controls, increasing in proportion to NYHA class severity.
Why the study?
Do plasma osteopontin levels and the frequency of osteopontin-expressing CD4+ T cells correlate with the severity of heart failure?
Population
131 subjects, comprising 93 consecutive patients with heart disease classified by NYHA functional class, and…
Design
Cross-sectional
Authors
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Osteopontin markers may aid HF severity assessment; hypothesis-generating from cross-sectional data.
Cross-Sectional (n=131)
No
Do plasma osteopontin levels and the frequency of osteopontin-expressing CD4+ T cells correlate with the severity of heart failure?
Absolute Event Rate: 27.3% vs 16.7%
p-value: p=<0.0001
Plasma osteopontin levels and the frequency of osteopontin-expressing CD4+ T cells are significantly elevated in patients with heart failure and correlate with disease severity, suggesting their potential utility as biomarkers.
Soejima et al. (2007) conducted a cross-sectional in Heart failure (n=131). Heart failure vs. Controls without heart disease was evaluated on Frequency of osteopontin-expressing CD4+ T cells (%) (p=<0.0001). Heart failure was associated with significantly higher frequencies of osteopontin-expressing CD4+ T cells (27.3% vs 16.7%) and plasma osteopontin levels compared to controls, increasing in proportion to NYHA class severity.
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