What is the clinical evidence from this study?

Study design: Other. Population: Myocardial remodeling. Intervention: Simvastatin vs. TNFalpha alone. Primary outcome: Myofibroblast proliferation, invasion and MMP-9 secretion.

August 21, 2004Cardiovascular ResearchOpen Access

Tumor necrosis factor ? induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin

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Key result

Simvastatin concentration-dependently inhibited TNFalpha-induced human atrial myofibroblast proliferation, invasion, and MMP-9 secretion.

Why the study?

Does simvastatin inhibit TNFalpha-induced proliferation, invasion, and MMP-9 secretion in human atrial myofibroblasts?

Population

Human cardiac myofibroblasts cultured from right atrial appendage

Comparison

Simvastatin in the presence of TNFalpha vs TNFalpha alone or untreated control

Design

Preclinical

Follow-up

4 days

Authors

KPKyle PorterIndiana University Health NTNeil A. TurnerGeneral Cardiology DODavid O’ReganKing's College London

Discussion

Member takes

Implication

May support statin anti-fibrotic effects in atria; leaves open clinical translation to remodeling prevention.

Structured PICO

Does simvastatin inhibit TNFalpha-induced proliferation, invasion, and MMP-9 secretion in human atrial myofibroblasts?

Population

In vitro study using human cardiac myofibroblasts cultured from right atrial appendages to evaluate the cellular effects of TNFalpha and simvastatin.

Intervention

Simvastatin (0.1-10 mumol/l) in the presence of TNFalpha

Comparator

TNFalpha alone or untreated control

Outcome

Cell proliferation, invasion, MMP-9 secretion, and MMP-9 mRNA expressionsurrogate

Simvastatin inhibits TNFalpha-induced proliferation, invasion, and MMP-9 secretion in human atrial myofibroblasts, suggesting a mechanism for statins in preventing adverse myocardial remodeling.

Cite This Study

Porter et al. (2004) studied Myocardial remodeling. Simvastatin vs. TNFalpha alone was evaluated on Myofibroblast proliferation, invasion and MMP-9 secretion. Simvastatin concentration-dependently inhibited TNFalpha-induced human atrial myofibroblast proliferation, invasion, and MMP-9 secretion.

synapsesocial.com/papers/6a207dddee274fb2963e8643 https://doi.org/10.1016/j.cardiores.2004.07.020

Topics

Statin therapy

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Tumor necrosis factor ? induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Topics

Tumor necrosis factor ? induces human atrial myofibroblast proliferation, invasion and MMP-9 secretion: inhibition by simvastatin

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider