Key result
Pediatric heart transplant recipients had significantly reduced LV and RV systolic and diastolic global and segmental long-axis velocities compared with controls (P < 0.05-0.001).
Why the study?
Endomyocardial biopsy for detecting allograft rejection in pediatric heart transplant recipients is invasive and carries complications, creating a need for noninvasive monitoring alternatives.
Does tissue phase mapping detect differences in myocardial velocities and dyssynchrony in pediatric heart transplant recipients compared to controls?
Case-Control (n=38)
Does tissue phase mapping detect differences in myocardial velocities and dyssynchrony in pediatric heart transplant recipients compared to controls?
Tissue phase mapping can noninvasively detect biventricular myocardial velocity differences in pediatric heart transplant patients that correlate with their rejection history.
Answers are grounded in this paper and cite their sources.
Tissue phase mapping may detect biventricular velocity abnormalities in pediatric transplant recipients; leaves open its role in rejection monitoring.
BACKGROUND: Endomyocardial biopsy (EMB) is the standard method for detecting allograft rejection in pediatric heart transplants (Htx). As EMB is invasive and carries a risk of complications, there is a need for a noninvasive alternative for allograft monitoring. PURPOSE: To quantify left and right ventricular (LV & RV) peak velocities, velocity twist, and intra-/interventricular dyssynchrony using tissue phase mapping (TPM) in pediatric Htx compared with controls, and to explore the relationship between global cardiac function parameters and the number of rejection episodes to these velocities and intra-/interventricular dyssynchrony. STUDY TYPE: Prospective. SUBJECTS: Twenty Htx patients (age: 16.0 ± 3.1 years, 11 males) and 18 age- and sex-matched controls (age: 15.5 ± 4.3 years, nine males). FIELD STRENGTH/SEQUENCE: 5T; 2D balanced cine steady-state free-precession (bSSFP), TPM (2D cine phase contrast with three-directional velocity encoding). ASSESSMENT: LV and RV circumferential, radial, and long-axis velocity-time curves, global and segmental peak velocities were measured using TPM. Short-axis bSSFP images were used to measure global LV and RV function parameters. STATISTICAL TESTS: A normality test (Lilliefors test) was performed on all data. For comparisons, a t-test was used for normally distributed data or a Wilcoxon rank-sum test otherwise. Correlations were determined by a Pearson correlation. RESULTS: Htx patients had significantly reduced LV (P < 0.05-0.001) and RV (P < 0.05-0.001) systolic and diastolic global and segmental long-axis velocities, reduced RV diastolic peak twist (P < 0.01), and presented with higher interventricular dyssynchrony for long-axis and circumferential motions (P < 0.05-0.001). LV diastolic long-axis dyssynchrony (r = 0.48, P = 0.03) and RV diastolic peak twist (r = -0.64, P = 0.004) significantly correlated with the total number of rejection episodes. DATA CONCLUSION: TPM detected differences in biventricular myocardial velocities in pediatric Htx patients compared with controls and indicated a relationship between Htx myocardial velocities and rejection history. LEVEL OF EVIDENCE: 2 Technical Efficacy Stage: 3 J. Magn. Reson. Imaging 2020;51:1212-1222.
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Berhane et al. (2019) conducted a case-control in Pediatric heart transplant (n=38). Heart transplant vs. Age- and sex-matched controls was evaluated on Left and right ventricular peak velocities, velocity twist, and intra-/interventricular dyssynchrony (p=<0.05-0.001). Pediatric heart transplant recipients had significantly reduced LV and RV systolic and diastolic global and segmental long-axis velocities compared with controls (P < 0.05-0.001).
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