What question did this study set out to answer?

This research aims to examine the differences in excitation thresholds between anodal and cathodal stimulation in cardiac muscle.

August 1, 1957American Journal of Physiology-Legacy Content

Anodal Excitation of Cardiac Muscle

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Why the study?

How do excitation thresholds differ between anodal and cathodal stimulation in dog ventricular myocardium?

Population

Dog ventricular myocardium

Comparison

Anodal stimulation vs Cathodal stimulation

Design

Preclinical

Authors

PCPaul F. CranefieldPlymouth Hospital BHBrian F. HoffmanBrunswick (United States)ASArthur A. SiebensMeridian Institute

Discussion

Member takes

Implication

Caution against applying anodal-cathodal differences to clinical pacing; hypothesis-generating for human translation studies.

Key Points

This research aims to examine the differences in excitation thresholds between anodal and cathodal stimulation in cardiac muscle.
Measured the strength-interval curve of dog ventricular myocardium during anodal and cathodal stimulation.
Analyzed thresholds during diastole and relative refractory periods.
Investigated the phenomenon of double origin excitation.
Anodal threshold is higher than cathodal during diastole; however, it varies during the refractory period.
Anodal stimulation can excite the myocardium exclusively during the early relative refractory period.
Double origin excitation occurs at strong stimuli without inducing fibrillation.

Structured PICO

How do excitation thresholds differ between anodal and cathodal stimulation in dog ventricular myocardium?

Population

Dog ventricular myocardium

Intervention

Anodal stimulation

Comparator

Cathodal stimulation

Outcome

Strength-interval curve and excitation thresholdssurrogate

This preclinical study demonstrates that anodal stimulation has a lower excitation threshold than cathodal stimulation during the relative refractory period in canine ventricular myocardium.

Cite This Study

Cranefield et al. (1957) studied this question.

synapsesocial.com/papers/6a2080f3df4cd797f4f42291 https://doi.org/10.1152/ajplegacy.1957.190.2.383

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Anodal Excitation of Cardiac Muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Anodal Excitation of Cardiac Muscle

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

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Also Consider