Key result
Pulsed-field ablation achieves ~88% procedural success for ventricular tachycardia with no acute complications.
Why the study?
Pulsed-field ablation needed evaluation as a potential non-thermal alternative to radiofrequency and cryo-ablation for treating ventricular tachycardia.
Does pulsed-field ablation safely and effectively eliminate ventricular tachycardia in human patients?
Systematic Review (n=8)
Does pulsed-field ablation safely and effectively eliminate ventricular tachycardia in human patients?
Pulsed-field ablation shows promising early safety and procedural success for ventricular tachycardia, although current evidence is strictly limited to early case reports and small series.
Supports early safety signal for pulsed-field ablation in ventricular tachycardia; leaves open randomized confirmation before practice change.
BACKGROUND: Pulsed-field ablation (PFA) is a cutting-edge technique that employs non-thermal energy to cause cell death by inducing irreversible electroporation of cell membranes. This systematic review evaluates the PFA effectiveness as a potential alternative to radiofrequency and cryo-ablation for treating ventricular tachycardia. METHODS: PubMed, Embase, Scopus, and Web of Science were systematically searched using keywords related to ventricular tachycardia and pulsed-field ablation. Eligible Studies evaluating this therapeutic approach for ventricular tachycardia were included in the final analysis. RESULTS: We included six studies (five case reports and one case series) in our systematic review. Eight (88.8%) of procedures were successful with 100% long-term efficacy. No procedural complications or ventricular tachycardia (VT) recurrence were observed in the cases. CONCLUSION: The absence of complications, high effectiveness, and long-term success rate make PFAs a good VT treatment option. However, PFA safety and efficacy studies for VT treatment are scarce. Thus, larger investigations on this topic are urgently needed.
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Askarinejad et al. (2024) conducted a systematic review in Ventricular tachycardia (n=8). Pulsed-field ablation was evaluated on Procedural success. Pulsed-field ablation for ventricular tachycardia achieved a procedural success rate of 87.5% with no procedural complications across eight reported cases.
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