What question did this study set out to answer?

This research examines how acute volume load affects refractoriness and arrhythmia development in chronically infarcted canine hearts.

March 1, 1989Circulation

Effect of acute volume load on refractoriness and arrhythmia development in isolated, chronically infarcted canine hearts.

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Why the study?

Does acute volume load alter refractoriness and increase arrhythmia inducibility in isolated, chronically infarcted canine hearts?

Key Points

This research examines how acute volume load affects refractoriness and arrhythmia development in chronically infarcted canine hearts.
Measured strength-interval curves in 14 isolated canine hearts with chronic infarctions at varying end-diastolic volumes.
Evaluated the inducibility of ventricular arrhythmias in 11 hearts at multiple sites with different volume loads.
Compared the effects of low and high volumes on absolute and relative refractory periods at normal and infarction sites.
At control sites, volume load reduced the absolute refractory period (178 to 175 msec, p < 0.05).
Infarcted sites showed a greater change: absolute refractory period decreased from 171.5 to 160.6 msec (p < 0.01), and relative refractory period from 180.1 to 169.9 msec (p = 0.05).
Four out of eight hearts had inducible tachyarrhythmias at high volume, showing significant shortening of the absolute refractory period (24.7 vs. 3.9 msec, p < 0.05).

Structured PICO

Does acute volume load alter refractoriness and increase arrhythmia inducibility in isolated, chronically infarcted canine hearts?

Population

14 isolated, blood perfused, canine hearts with chronic (greater than 25 days) infarctions

Intervention

High end-diastolic volume (48 +/- 6 ml)

Comparator

Low end-diastolic volume (22 +/- 5 ml)

Outcome

Changes in absolute and relative refractory periods, and inducibility of ventricular arrhythmiassurrogate

Acute volume loading significantly shortens refractoriness and increases the inducibility of ventricular arrhythmias in chronically infarcted canine hearts, suggesting a mechanism for stretch-induced arrhythmias in pathologic conditions.

Discussion

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Implication

Acute volume load may heighten arrhythmia inducibility in infarcted hearts; hypothesis-generating for human post-MI stretch effects.

Cite This Study

Calkins et al. (1989) studied this question.

synapsesocial.com/papers/6a2082d9cd682a52c6f89cc0 https://doi.org/10.1161/01.cir.79.3.687

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Effect of acute volume load on refractoriness and arrhythmia development in isolated, chronically infarcted canine hearts.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Effect of acute volume load on refractoriness and arrhythmia development in isolated, chronically infarcted canine hearts.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

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