What question did this study set out to answer?

This study examines how exposure to social stress influences vasodilator responses in hypertensive mice.

March 1, 1987HypertensionOpen Access

Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice.

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This study examines how exposure to social stress influences vasodilator responses in hypertensive mice.
Hypertensive CBA Agouti mice were exposed to social stress for 2 months.
Vasodilator responses were evaluated using hindquarter vascular beds and aortic strips.
Responses to acetylcholine and other vasodilators were measured after inducing contractile tone.
Hypertensive mice exhibited increased sensitivity to acetylcholine with lower doses required for vasodilation.
No difference in responsiveness to nitroprusside between hypertensive and normotensive mice.
Aortic tissues from hypertensive mice displayed significant increased sensitivity to acetylcholine and A23187.

Structured PICO

Population

CBA Agouti mice made hypertensive by exposure to social stress in a complex population cage for 2 months, and normotensive control mice

Intervention

Administration of endothelium-dependent vasodilators (acetylcholine and A23187) and endothelium-independent vasodilators (nitroprusside and 8-bromo cGMP)

Comparator

Normotensive mice

Outcome

Vasodilator responsiveness measured by changes in perfusion pressure in the hindquarter vascular bed and isometric force generation in aortic stripssurrogate

Psychosocial hypertension in mice is associated with increased responsiveness to endothelium-dependent vasodilators.

Discussion

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Implication

Enhanced endothelial sensitivity in hypertensive mice warrants no clinical translation; leaves open compensatory mechanisms in psychosocial hypertension models.

Cite This Study

Webb et al. (1987) studied this question.

synapsesocial.com/papers/6a2084c347fdc8d429f4254d https://doi.org/10.1161/01.hyp.9.3.268

Topics

Hypertension management

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Implication

Enhanced endothelial sensitivity in hypertensive mice warrants no clinical translation; leaves open compensatory mechanisms in psychosocial hypertension models.

Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Topics

Increased vasodilator responses to acetylcholine in psychosocial hypertensive mice.

Key Points

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

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