What question did this study set out to answer?

The aim is to determine if enhanced responsiveness to angiotensin II contributes to hypertension in CBA mice exposed to social stress.

March 1, 1983HypertensionOpen Access

Increased vascular sensitivity to angiotensin ii in psychosocial hypertensive mice.

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Why the study?

Does angiotensin II elicit enhanced pressor responsiveness in the hindquarter and renal vasculatures of psychosocial hypertensive mice compared to normotensive mice?

Key Points

The aim is to determine if enhanced responsiveness to angiotensin II contributes to hypertension in CBA mice exposed to social stress.
Examined effects of angiotensin II on hindquarter and renal vasculatures in 13 hypertensive and 13 normotensive mice
Pump-perfused vascular beds at constant flow using plasma substitute
Compared threshold and maximal pressor responses to angiotensin II and norepinephrine.
Hypertensive mice showed significant threshold constrictor responses to angiotensin II at lower doses than normotensive mice.
Maximal pressor responses to angiotensin II were greater in the hindquarters of hypertensive mice; renal responses were similar between groups.
Vasoconstrictor sensitivity to norepinephrine increased in hypertensive mice's hindquarters, but responses in renal vasculatures were similar to normotensive mice.

Structured PICO

Does angiotensin II elicit enhanced pressor responsiveness in the hindquarter and renal vasculatures of psychosocial hypertensive mice compared to normotensive mice?

Population

26 CBA mice (13 hypertensive from psychosocial model, 13 normotensive)

Intervention

Angiotensin II and norepinephrine administration to pump-perfused hindquarter and renal vasculatures

Comparator

Normotensive CBA mice

Outcome

Pressor responsiveness (threshold constrictor responses and maximal pressor responses)surrogate

Hyperresponsiveness to angiotensin II in resistance vessels plays an important role in maintaining elevated blood pressure in a psychosocial mouse model of hypertension.

Discussion

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Implication

Hyperresponsiveness to AII may sustain hypertension in this psychosocial mouse model; hypothesis-generating and requires human confirmation before clinical consideration.

Cite This Study

Webb et al. (1983) studied this question.

synapsesocial.com/papers/6a1fe2f717bd4d7ccf049ce7 https://doi.org/10.1161/01.hyp.5.2_pt_2.i165

Topics

Hypertension management

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Implication

Hyperresponsiveness to AII may sustain hypertension in this psychosocial mouse model; hypothesis-generating and requires human confirmation before clinical consideration.