Population
Conscious mice and rats with indwelling femoral arterial and venous catheters
Comparison
Continuous intravenous infusion of angiotensin… vs Comparison between species and across different…
Design
Preclinical
Authors
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Caution extrapolating ACEi/ARB responses from mice to rats; leaves open species-specific RAS dependence in cardiovascular models.
Mice exhibit greater dependence on the endogenous renin-angiotensin system for blood pressure maintenance but higher resistance to exogenous angiotensin II compared to rats, highlighting important species differences in preclinical cardiovascular models.
Cholewa et al. (2005) studied this question.
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