Why the study?
Does alteration of sodium intake and ANG II infusion affect the renin-angiotensin-aldosterone axis and mean arterial pressure in conscious mice?
Population
Conscious mice
Comparison
High sodium intake and/or continuous infusion of… vs Low sodium intake and/or vehicle infusion
Design
Preclinical
Authors
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ANG II suppression may maintain salt resistance in mice; leaves open translation to human hypertension.
Does alteration of sodium intake and ANG II infusion affect the renin-angiotensin-aldosterone axis and mean arterial pressure in conscious mice?
Physiological suppression of circulating ANG II appears necessary to maintain constant arterial pressure during increased sodium intake in normal mice.
Cholewa et al. (2001) studied this question.
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