Why the study?
Are platelet half-life, plasma thromboxane B2 levels, and circulating endothelial cells altered in patients with peripheral vascular disease compared to controls?
Population
107 patients with angiographically proven peripheral vascular disease (PVD), mean age 63 ± 6.8 years.
Design
Cross-sectional
Authors
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May indicate platelet activation in PVD; hypothesis-generating and should not yet change practice.
Are platelet half-life, plasma thromboxane B2 levels, and circulating endothelial cells altered in patients with peripheral vascular disease compared to controls?
Patients with peripheral vascular disease exhibit enhanced platelet consumption and activity, as well as increased endothelial damage, particularly in those who smoke or have advanced clinical stages.
Sinzinger et al. (1986) studied this question.
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