Key result
Advanced imaging techniques, such as magnetization transfer and diffusion tensor imaging, offer increased sensitivity and specificity for monitoring disease progression in progressive multiple sclerosis.
Advanced imaging techniques offer promising biomarkers for monitoring disease progression and evaluating treatment efficacy in clinical trials for progressive multiple sclerosis.
May aid progressive MS monitoring; leaves open prospective validation before clinical adoption.
Imaging markers for monitoring disease progression in progressive multiple sclerosis (PMS) are scarce, thereby limiting the possibility to monitor disease evolution and to test effective treatments in clinical trials. Advanced imaging techniques that have the advantage of metrics with increased sensitivity to short-term tissue changes and increased specificity to the structural abnormalities characteristic of PMS have recently been applied in clinical trials of PMS. In this review, we (1) provide an overview of the pathological features of PMS, (2) summarize the findings of research and clinical trials conducted in PMS which have applied conventional and advanced magnetic resonance imaging techniques and (3) discuss recent advancements and future perspectives in monitoring PMS with imaging techniques.
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Petracca et al. (2018) conducted a review in Progressive Multiple Sclerosis. Advanced imaging techniques vs. Conventional MRI was evaluated. Advanced imaging techniques, such as magnetization transfer and diffusion tensor imaging, offer increased sensitivity and specificity for monitoring disease progression in progressive multiple sclerosis.
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