Key result
Nocturnal systolic blood pressure was a strong predictor of left ventricular mass index in both normotensive (beta=0.38, p=0.02) and treated hypertensive (beta=0.39, p=0.03) elderly subjects.
Why the study?
Does nocturnal blood pressure predict left ventricular mass index in normotensive and treated hypertensive elderly subjects?
Observational (n=71)
Does nocturnal blood pressure predict left ventricular mass index in normotensive and treated hypertensive elderly subjects?
Effect estimate: beta = 0.38 (normotensive), beta = 0.39 (hypertensive)
p-value: p = 0.02 (normotensive), p = 0.03 (hypertensive)
Nocturnal systolic blood pressure is a strong predictor of left ventricular mass index in elderly subjects, even those considered normotensive based on daytime clinic readings.
May warrant nocturnal BP monitoring for LV mass risk stratification in elderly; extends associations yet leaves causal role open.
Blood pressure (BP) predictors of left ventricular mass index (LVMI) were studied in 40 healthy normotensive (71.4 +/- 4.4 years) and 31 hypertensive (73.5 +/- 4.8 years) elderly community-dwelling subjects using short-axis cardiac cine magnetic resonance imaging and 24-h ambulatory BP monitoring. Mean night-time BPs were calculated from the average of readings during sleep and mean daytime BPs were calculated from the remaining recordings. The hypertensive subjects were all receiving anti-hypertensive therapy with angiotensin-converting enzyme (ACE) inhibitors, calcium-channel blockers, beta-blockers or diuretics. Nocturnal systolic BP was a strong predictor of LVMI in both normotensive (beta = 0.38, p = 0.02) and treated hypertensive (beta = 0.39, p = 0.03) subjects. By contrast, daytime systolic BP was a weaker predictor of LVMI in the treated hypertensives (beta = 0.36, p = 0.04) and did not predict LVMI in the normal subjects (beta = 0.27, NS). Nocturnal BP may partly explain the increase in LVMI with ageing in subjects thought to be normotensive on the basis of daytime clinic BP recordings.
No takes yet. Share an insight, caveat, or question.
Morfis et al. (2002) conducted an observational in Normotension and hypertension (n=71). Nocturnal blood pressure vs. Daytime blood pressure was evaluated on Left ventricular mass index (LVMI) (beta = 0.38 (normotensive), beta = 0.39 (hypertensive), p=p = 0.02 (normotensive), p = 0.03 (hypertensive)). Nocturnal systolic blood pressure was a strong predictor of left ventricular mass index in both normotensive (beta=0.38, p=0.02) and treated hypertensive (beta=0.39, p=0.03) elderly subjects.
Synapse has enriched 4 closely related papers on similar clinical questions. Consider them for comparative context: