Why the study?
Does (pro)renin receptor blocker peptide prevent glomerulosclerosis and proteinuria in human (pro)renin receptor-transgenic rats?
Population
Transgenic rats overexpressing the human (pro)renin receptor
Comparison
In vivo infusion of therenin receptor blocker… vs Wild-type rats or untreated transgenic rats
Design
Preclinical
Follow-up
28 weeks of age
Authors
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Should not change practice in proteinuric kidney disease; leaves open (pro)renin receptor blockade as a novel target.
Does (pro)renin receptor blocker peptide prevent glomerulosclerosis and proteinuria in human (pro)renin receptor-transgenic rats?
The human (pro)renin receptor elicits slowly progressive nephropathy via AngII-independent MAPK activation, which can be inhibited by a specific receptor blocker peptide but not by ACE inhibitors.
Kaneshiro et al. (2007) studied this question.
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