What question did this study set out to answer?

The study aims to determine how acute coronary artery hypertension affects constrictor responses to serotonin through endothelial function.

December 1, 1987Circulation ResearchOpen Access

Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo.

View Full Paper

Ask AI

Bookmark

Population

Open-chest anesthetized dogs (blood perfused dog heart)

Comparison

Brief periods of coronary hypertension vs Control perfusion pressure of 80 mm Hg

Design

Preclinical

Follow-up

at least 2.5 hours

Authors

KLKathryn G. LampingUniversity of Iowa WDWilliam P. DoleNovartis (United States)

Discussion

Member takes

Implication

Hypothesis-generating for endothelial impairment in acute hypertension; leaves open translation to human coronary vasoreactivity.

Key Points

The study aims to determine how acute coronary artery hypertension affects constrictor responses to serotonin through endothelial function.
Conducted experiments on anesthetized dogs with a focus on the left anterior descending coronary artery.
Examined responses to serotonin, angiotensin II, and methoxamine before and after induced hypertension.
Measured coronary diameter using piezoelectric crystals before and after hypertension.
Acute hypertension increased constriction of large coronary arteries to serotonin significantly (delta D = -207 +/- 45 microns at 50 micrograms/min; p < 0.05).
Effects of hypertension on constriction persisted for at least 2.5 hours post hypertension.
Hypertension did not affect responses to angiotensin II or methoxamine, highlighting specificity.

Structured PICO

Population

Open-chest anesthetized dogs (blood perfused dog heart)

Intervention

Brief periods of coronary hypertension (perfusion pressure of 200 mm Hg for 10 seconds to 15 minutes)

Comparator

Control perfusion pressure of 80 mm Hg

Outcome

Change in large coronary artery diameter in response to intracoronary infusion of serotoninsurrogate

Acute coronary hypertension selectively potentiates serotonin-induced constriction of large coronary arteries by impairing endothelial function rather than directly affecting vascular smooth muscle.

Cite This Study

Lamping et al. (1987) studied this question.

synapsesocial.com/papers/6a20935c95285195790c9155 https://doi.org/10.1161/01.res.61.6.904

Topics

Hypertension management

View Full Paper

Ask AI

Bookmark

Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Topics

Acute hypertension selectively potentiates constrictor responses of large coronary arteries to serotonin by altering endothelial function in vivo.

Discussion

Member takes

Implication

Key Points

Structured PICO

Cite This Study

Also Consider

Topics

Also Consider