Key result
Orthostatic hypotension at baseline was significantly associated with an increased risk of incident dementia of at least 25% over 12 years of follow-up.
Why the study?
Does orthostatic hypotension increase the risk of incident dementia in elderly individuals?
Population
7,425 elderly individuals from the Three-City study cohort
Comparison
Presence of orthostatic hypotension at baseline vs Absence of orthostatic hypotension at baseline
Design
Cohort
Follow-up
12 years
Authors
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May flag higher-risk elderly for monitoring; leaves open causality and need for interventional trials.
Cohort (n=7,425)
Yes
Does orthostatic hypotension increase the risk of incident dementia in elderly individuals?
Effect estimate: increased risk of at least 25%
Orthostatic hypotension is associated with a significantly increased risk of incident dementia in elderly individuals, suggesting it could serve as a simple clinical marker to identify high-risk patients.
Crémer et al. (2017) conducted a cohort in Incident dementia (n=7,425). Orthostatic hypotension vs. Absence of orthostatic hypotension was evaluated on Incident dementia (increased risk of at least 25%). Orthostatic hypotension at baseline was significantly associated with an increased risk of incident dementia of at least 25% over 12 years of follow-up.
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