Key result
Delayed or prolonged orthostatic hypotension linked to ~70% higher risk of MCI or dementia.
Why the study?
Whether orthostatic hypotension contributes to clinical progression to mild cognitive impairment or dementia, and whether risk differs between early versus delayed and/or prolonged orthostatic hypotension, was unclear.
Does delayed and/or prolonged orthostatic hypotension increase the risk of clinical progression to mild cognitive impairment or dementia?
Population
1,882 patients from the Amsterdam Dementia Cohort
Comparison
Patients with early OH or delayed and/or prolonged OH vs patients without OH
Design
Cohort study
Follow-up
Mean (SD) 2.2 (1.4) years
Authors
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DPOH was associated with faster progression in SCD/MCI patients; leaves open whether screening or treatment alters outcomes.
Cohort (n=1,882)
No
Does delayed and/or prolonged orthostatic hypotension increase the risk of clinical progression to mild cognitive impairment or dementia?
Hazard Ratio: 1.7 (95% CI 1.1–2.7)
Delayed and prolonged orthostatic hypotension, but not early orthostatic hypotension, is a significant risk factor for clinical progression to mild cognitive impairment or dementia.
Kleipool et al. (2019) conducted a cohort in Subjective cognitive decline, mild cognitive impairment, or dementia (n=1,882). Delayed and/or prolonged orthostatic hypotension vs. No orthostatic hypotension was evaluated on Clinical progression to mild cognitive impairment or dementia (HR 1.7, 95% CI 1.1-2.7). Delayed and/or prolonged orthostatic hypotension significantly increased the risk of clinical progression to mild cognitive impairment or dementia compared to patients without orthostatic hypotension (HR 1.7).
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