Key result
Orthostatic hypotension in hypertensive adults aged ≥80 years was associated with an increased risk of cognitive decline (HR 1.36; 95% CI 1.14-1.59).
Why the study?
Does orthostatic hypotension increase the risk of cognitive decline or dementia in older hypertensive adults?
Population
3,121 hypertensive adults aged ≥80 years from the Hypertension in the Very Elderly Trial (HYVET) cohort.
Comparison
Presence of orthostatic hypotension or… vs Absence of orthostatic hypotension or…
Design
Cohort
Authors
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Orthostatic hypotension may mark higher cognitive decline risk; hypothesis-generating and should not yet change practice.
Cohort (n=3,121)
Does orthostatic hypotension increase the risk of cognitive decline or dementia in older hypertensive adults?
Hazard Ratio: 1.36 (95% CI 1.14–1.59)
Orthostatic hypotension and symptomatic subclinical orthostatic hypotension are associated with a significantly increased risk of cognitive decline and dementia in the hypertensive oldest-old.
Peters et al. (2018) conducted a cohort in Hypertension (n=3,121). Orthostatic hypotension vs. No orthostatic hypotension was evaluated on Cognitive decline (HR 1.36, 95% CI 1.14-1.59). Orthostatic hypotension in hypertensive adults aged ≥80 years was associated with an increased risk of cognitive decline (HR 1.36; 95% CI 1.14-1.59).
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