Sera From Children After Cardiopulmonary Bypass Reduces Permeability of Capillary Endothelial Cell Barriers

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To understand how sera from children after cardiopulmonary bypass affects capillary endothelial cell barriers.
Cohort study with twenty children undergoing cardiopulmonary bypass for congenital heart disease.
Serum collected at three time points: before, 2 hours after, and 18 hours after bypass.
Effects on endothelial cell function and structure measured using transendothelial electrical resistance and immunofluorescence microscopy.
Post-bypass sera induced a transient increase in barrier function but less overall disruption compared to pre-bypass sera.
Immunofluorescence showed less disruption in claudin-5 and VE-cadherin junctions with post-bypass sera.
No significant changes in inflammatory gene expression were observed in any sera.

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Cohort study examines serum effects on capillary barrier function in children post-surgery, indicating reduced permeability.

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Pierce et al. (2018) studied this question.

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