Why the study?
Does sex steroid administration alter arterial stiffness and its relationship with fasting insulin levels in transsexual individuals?
Population
30 transsexual individuals (12 male-to-female and 18 female-to-male)
Comparison
Ethinyl estradiol and cyproterone acetate or… vs Baseline (pre-treatment values)
Design
Cohort
Follow-up
12 months
Authors
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May increase arterial stiffness in genetic men on cross-sex hormones; hypothesis-generating and should not yet change practice.
Does sex steroid administration alter arterial stiffness and its relationship with fasting insulin levels in transsexual individuals?
Short-term administration of estrogens and antiandrogens increases femoral and brachial artery stiffness in genetic men, while fasting insulin is a stronger determinant of arterial stiffness in genetic women.
Giltay et al. (1999) studied this question.
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