Population
Acutely isolated medial habenula (MHb) neurons from rats
Design
Preclinical
Authors
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May explain low-dose nicotine effects via desensitization; leaves open translation from rat habenula to human dependence.
Nicotine induces rapid activation and pronounced desensitization of nicotinic acetylcholine receptors in rat medial habenula neurons, with desensitization occurring at much lower concentrations than activation.
Lester et al. (1995) studied this question.
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